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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Dysregulation of neuroprotective astrocytes, a spectrum of microglial activation states, and altered hippocampal neurogenesis are revealed by single-cell RNA sequencing in prion disease

Fig. 5

Monocle trajectory analysis of microglia categorized into 5 transcriptional subtypes. A The relative frequency of each microglia sub-cluster is plotted for the cortex and hippocampus of RML and Mock infected mice. p values s were calculated using non-parametric Mann–Whitney U tests. * p values  < 0.1, ** p values  < 0.05, *** p values  < 0.01. All p values are provided in Additional file 9. B UMAP projection plot of all 99,756 microglial transcriptomes with color mapping to transcriptional pseudotime calculated with Monocle. Cells from cluster micro.4 were supplied to serve as the root for calculating transcriptional pseudotime and trajectories. C UMAP projection plot with color mapping to microglial subtypes

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Acta Neuropathologica Communications

ISSN: 2051-5960

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