Fig. 3

Assessment of risk like behavior at 5 months Post‐GW toxic exposure and for both Sexes. a, b For both Sex, mice in both mTBI groups developed an increased risk-taking behavior by spending more time in the open arms of the elevated plus maze when compared with their respective sham control, (c, *** P < 0.0001 and P < 0.00001 Two-Way ANOVA-Tukey). Sham/GW exposed animals performed the opposite of the mTBI groups displaying a greater anxiety by spending less time in the open 'arms and more time in the closed arms (c, f, P < 0.05 Two-Way ANOVA-Tukey). A three-Way ANOVA analysis for the time spent in the open arm revealed a Sex, Injury and Exposure effect: F_{(1, 175)} = 4.47 P=0.0358; F_{(1, 175)} = 74.62 P < 0.0001; F_{(1, 175)} = 7.59 P = 0.0065 respectively, but no interaction effect. A three-Way ANOVA analysis for the time spent in the closed arm revealed an Injury and Exposure effect: F_{(1, 179)} = 63.19 P < 0.0001; F_{(1, 179)} = 11.36 P = 0.0009; but no Sex effect F_{(1, 179)} = 0.1525 P = 0.696. Data are presented as Whiskers plots: Min to Max. Each symbol represents 1 mouse N = 22/24 per group per Sex)