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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Phosphorylation of β-catenin at Serine552 correlates with invasion and recurrence of non-functioning pituitary neuroendocrine tumours

Fig. 7

Protein kinase A (PKA) and AKT1 as hyperphosphorylated in recurrent NF-PitNETs. a, b Motif enrichment analysis using Motif-x identified the kinases up-regulated in recurrent  NF-PitNETs. ce Ms quantitation of PRKAR2A pSer78, PRKAR1A pSer83, and AKT pSer124 showed increased phosphorylation in recurrent NF-PitNETs. c Increased phosphorylation of PRKAR2A pSer78, a regulatory subunit of PKA was statistically significant. Immunohistochemistry against PRKAR1A pSer83 in non-recurrent (f) and recurrent (g) tumours showed upregulation of PRKAR1A pSer 83 in NF-PitNETs recurrent tumours. h Quantification of H-score of non-recurrent f and recurrent g tumours revealed hyperphosphorylation of PRKAR1A pSer83 in recurrent NF-PitNETs. Two-tailed unpaired Student’s t-test was performed. **p < 0.001, ****p < 0.0001. Scale bar represents 50 μm

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