Fig. 6

The H-score of β-catenin pSer552 correlates with the recurrence free survival of NF-PitNETs. a H-score of immunohistochemistry of β-catenin pSer552 shows significant increase in phosphorylation in recurrent (R) NF-PitNETs as compared to invasive (I) and non-invasive/non-recurrent (NI/NR) NF-PitNETs. b Receiver operating characteristic (ROC) curve for the prognosis of recurrent NF-PitNETs. ROC was performed for H-score of recurrent (n = 44) and non-recurrent (n = 156) NF-PitNETs. Area under the curve (AUC) 0.710 (p < 0.001) indicates that β-catenin pSer552 can distinguish between recurrent and non-recurrent NF-PitNETs. c Kaplan–Meier recurrence-free survival of the 200 NF-PitNETs patients after surgery according to the H-score cut-off level of 160 of β-catenin pSer552. β-catenin pSer552 H-score level > 160 was found to be an independent predictor of tumour NF-PitNETs recurrence (Logrank (Mantel-Cox test) p < 0.0001)