Table 1 Individuals with two C9orf72 intermediate-length alleles in ALS, FTD, FTD spectrum, PD and AD patients, and controls after exclusion of expansion carriers
Trait | Shorter/longer allele | Controls with longer alleles (%) | Cases with longer alleles (%) | p-value | OR [95% CI] |
|---|---|---|---|---|---|
ALS | < 7/ < 7 vs. = > 7/ = > 7 | 546 (5.7%) | 132 (6.4%) | 0.97 | 0.99 [0.76–1.31] |
< 7/ < 7 vs. 7–16/7–16 | 500 (5.3%) | 121 (5.9%) | 0.88 | 0.98 [0.74–1.30] | |
< 7/ < 7 vs. = > 7/ = > 17–45 | 46 (0.5%) | 11 (0.5%) | 0.60 | 1.28 [0.51–3.23] | |
FTD | < 7/ < 7 vs. = > 7/ = > 7 | 546 (5.7%) | 71 (7%) | 0.99 | 1.00 [0.72–1.39] |
< 7/ < 7 vs. 7–16/7–16 | 500 (5.3%) | 64 (6.3%) | 0.96 | 0.99 [0.70–1.40] | |
< 7/ < 7 vs. = > 7/ = > 17–45 | 46 (0.5%) | 7 (0.7%) | 0.86 | 1.09 [0.40–3.00] | |
FTD spectrum | < 7/ < 7 vs. = > 7/ = > 7 | 546 (5.7%) | 217 (6.6%) | 0.86 | 0.98 [0.79–1.22] |
< 7/ < 7 vs. 7–16/7–16 | 500 (5.3%) | 199 (6.1%) | 0.81 | 0.97 [0.78–1.22] | |
< 7/ < 7 vs. = > 7/ = > 17–45 | 46 (0.5%) | 18 (0.5%) | 0.90 | 1.05 [0.50–2.20] | |
PD | < 7/ < 7 vs. = > 7/ = > 7 | 546 (5.7%) | 22 (7%) | 0.94 | 1.02 [0.59–1.76] |
< 7/ < 7 vs. 7–16/7–16 | 500 (5.3%) | 21 (6.7%) | 0.73 | 1.10 [0.63–1.94] | |
< 7/ < 7 vs. = > 7/ = > 17–45 | 46 (0.5%) | 1 (0.3%) | 0.41 | 0.41 [0.05–3.50] | |
AD | < 7/ < 7 vs. = > 7/ = > 7 | 546 (5.7%) | 67 (6.8%) | 0.48 | 0.88 [0.60–1.27] |
< 7/ < 7 vs. 7–16/7–16 | 500 (5.3%) | 60 (6.1%) | 0.45 | 0.86 [0.58–1.27] | |
< 7/ < 7 vs. = > 7/ = > 17–45 | 46 (0.5%) | 7 (0.7%) | 0.99 | 1.00 [0.33–3.02] |