Fig. 5
From: Tau seeding activity in various regions of down syndrome brain assessed by two novel assays
Tau seeding activity is positively correlated with the levels of hyperphosphorylated tau in DS and control brains. a. Representative immuno-dot blots of phosphorylated tau in the DS and control brain extracts developed with AT8 (pS202/pT205), anti-pT217-tau, and PHF-1 (pS396/404). b. Level of phosphorylated tau in brain extracts of temporal cortex (TC), frontal cortex (FC), occipital cortex (OC), corpus callosum (CC), and cerebellar cortex (CBC) from DS and control cases and presented as scatter plots with mean ± SD. *,#, or &P < 0.05; ** or &&P < 0.01; **** or ####P < 0.0001. c, d. Levels of phosphorylated tau at Ser202/Thr205 (AT8), Thr217, and Ser396/404 (PHF-1) in TC, FC, and OC (c), and all five regions (d) were plotted against levels of captured tau. Linear- or non-linear-regression between levels of captured tau and phosphorylated tau were performed