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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression

Fig. 3

Behavioural outputs of WT and α-DB KO mice on the ERC task. Both WT and α-DB KO mice completed significantly fewer trials between ERC16, ERC32 and ERC64 (a). The number of completed trials increased significantly between ERC64 and FR64 in both mouse groups (a). In addition, α-DB KO mice completed significantly more trials than WT mice on the ERC64 and FR64 tasks (b). The amount of food consumed during the trial was significantly increased between the ERC16, ERC32 and ERC64 schedules in both WT and KO mice (c). Food intake did not differ between WT and α-DB KO mice during any of the ERC tasks (d). Total touches decreased significantly between ERC16, ERC32 and ERC64 in WT mice but remained stable in KO animals (e), while KO mice made more touches than WT animals in ERC64 and FR64 (f). n = 12/group. For within-group comparisons (a, c, e), a = p < 0.01 vs. ERC32, b = p < 0.05 vs. ERC64, c = p < 0.01 vs. ERC64, d = p < 0.001 vs ERC64, e = p < 0.05 vs. FR64, f = p < 0.01 vs. FR64, g = p < 0.001 vs FR64, two-way repeated measures ANOVA with Sidak’s post-hoc. For between-group comparisons (b, d, f), *p < 0.05, **p < 0.01, ***p < 0.001 vs KO, two-way repeated measures ANOVA with Sidak’s post-hoc

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