Fig. 9
From: Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models
Citrullinated protein aggregates are highly colocalized with myelin proteins PLP and MBP and show less co-localization with MAG and MOG in the spinal cord white matter of SOD1G93A mice. Double immunofluorescence staining for citrullinated proteins and PLP (A), MBP (B), MAG (C), and MOG (D). E Mander’s colocalization coefficient of citrullinated protein aggregates and PLP, MBP, MAG, and MOG, respectively. The ages of nTg mice are as described in Fig. 2. Arrowheads point to citrulline-positive protein aggregates that overlap with the myelin proteins. Asterisks mark citrulline-positive protein aggregates that do not overlap with the myelin proteins