Fig. 8
From: Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models
Most citrullinated protein aggregates do not colocalize with disease-specific mutant protein and ubiquitinated protein aggregates in the spinal cord white matter. Double immunofluorescence staining for A C4F6 and citrullinated protein in SOD1G93A mice, B ubiquitin and citrullinated protein in SOD1G93A mice, C V5 and citrullinated protein in PFN1C71G mice, and D ubiquitin and citrullinated protein in PFN1C71G mice. E Mander’s colocalization coefficient for citrullinated protein aggregates overlapping with disease-associated and ubiquitin-positive protein aggregates in SOD1G93A and PFN1C71G mice. The ages of nTg mice are as described in Fig. 2. Arrowheads point to C4F6-positive, V5-positive, or ubiquitin-positive citrullinated protein aggregates