Fig. 10
From: Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models
Citrullinated protein aggregates are highly colocalized with myelin proteins PLP and MBP, less with MAG and MOG in the spinal cord white matter of PFN1C71G mice. Double immunofluorescence staining for citrullinated proteins and PLP (A), MBP (B), MAG (C), and MOG (D). E Mander’s colocalization coefficient of citrullinated protein aggregates and PLP, MBP, MAG, and MOG, respectively. The ages of nTg mice are as described in Fig. 2. Arrowheads point to citrulline-positive protein aggregates that overlap with the myelin proteins. Asterisks mark citrulline-positive protein aggregates that do not overlap with the myelin proteins