Fig. 1
From: Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models
Protein citrullination (PC) is increased during disease progression. A, C Western blots of citrullinated proteins from lumber spinal cords of SOD1G93A and PFN1C71G ALS mice at different disease stages (see Methods for disease stage definition), and their age-matched non-transgenic (nTg) controls. B, D Quantification of lane signal density in blots as illustrated in A and C, respectively. n = 4 in all groups. Statistics: unpaired t test for comparing transgenic mice with their age matched controls. **p < 0.01; ****p < 0.0001. E Comparison of PC in the spinal cords of SOD1G93A mice at paralysis stage with the age-matched nTg and SOD1 wild type (WT) transgenic mice. F Same as E but for PFN1C71G, PFN1WT and nTg mice. Presym = presymptomatic