Table 2 Human autopsy cases used for quantification of neuronal density (CA1 hippocampus) and local accumulation of pMLKL, pTDP-43 and pTau
From: LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease
Case nr | Group | AβMTL Phase | Braak NFT Stage | Age | Sex | CDR Score | LATE-NC Stage | GVD Stage | Additional neuropathology | APOE status |
|---|---|---|---|---|---|---|---|---|---|---|
1 | Control | 0 | 0 | 66 | f | 0 | 0 | 0 | AS, AGD | 3/3 |
2 | Control | 0 | 0 | 62 | m | 0 | 0 | 0 | – | 3/3 |
3 | Control | 0 | 1 | 46 | m | 0 | 0 | 0 | – | 3/3 |
4 | Control | 0 | 0 | 32 | m | 0 | 0 | 0 | – | NA |
5 | Control | 0 | 1 | 45 | m | 0 | 0 | 0 | – | 3/4 |
6 | Control | 0 | 0 | 18 | m | 0 | 0 | 0 | – | 3/3 |
7 | Control | 0 | 1 | 54 | m | 0 | 0 | 0 | – | 3/3 |
8 | Control | 0 | 1 | 59 | f | 3* | 0 | 0 | CAA | 2/3 |
9 | Control | 0 | 0 | 67 | m | 0 | 0 | 0 | – | 3/3 |
10 | ADTDP− | 3 | 2 | 82 | m | 3 | 0 | 0 | – | 3/3 |
11 | ADTDP− | 3 | 4 | 79 | f | NA | 0 | 4 | Microinfarcts | 3/3 |
12 | ADTDP− | 4 | 4 | 87 | f | 3 | 0 | 3 | AS, CAA | 3/3 |
13 | ADTDP− | 3 | 3 | 85 | m | 2 | 0 | 2 | CAA, microinfarcts | 3/4 |
14 | ADTDP− | 3 | 3 | 81 | m | 2 | 0 | 1 | AGD | 3/3 |
15 | ADTDP− | 4 | 4 | 83 | m | 1 | 0 | 2 | CAA, infarcts, microinfarcts | 3/4 |
16 | ADTDP− | 4 | 4 | 72 | f | 1 | 0 | 2 | Infarcts | 3/3 |
17 | ADTDP− | 4 | 5 | 78 | f | 3 | 0 | 1 | LBs, infarcts, SVD | 4/4 |
18 | ADTDP+ | 4 | 6 | 87 | m | 2 | 2 | 5 | – | 3/3 |
19 | ADTDP+ | 4 | 5 | 71 | m | 3 | 2 | 3 | – | 4/4 |
20 | ADTDP+ | 4 | 6 | 57 | m | 3 | 2 | 3 | – | 3/4 |
21 | ADTDP+ | 4 | 5 | 76 | m | 3 | 3 | 5 | ARTAG | 3/4 |
22 | ADTDP+ | 4 | 6 | 74 | m | 2 | 3 | 5 | – | 3/3 |
23 | ADTDP+ | 4 | 5 | 81 | f | 3 | 2 | 5 | CAA, infarcts | 3/3 |
24 | ADTDP+ | 4 | 5 | 78 | f | 3 | 2 | 5 | – | 3/4 |
25 | ADTDP+ | 4 | 4 | 89 | f | 2 | 2 | 4 | CAA, mild AS | 3/4 |
26 | ADTDP+ | 4 | 4 | 98 | f | 0.5 | 2 | 5 | Infarcts, SVD | 3/4 |
27 | ADTDP+ | 4 | 5 | 89 | f | 3 | 2 | 4 | CAA | 3/4 |