Fig. 5
From: LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease
Proposed TDP-43, pTau and pMLKL interplay in AD. Aβ and TDP-43 pathologies accelerate pTau pathology in AD (black and orange arrows, respectively). We also hypothesize that TDP-43 exacerbates necrosome-positive GVD lesions through pTau (blue arrow), giving rise to neurons bearing tangles, pTDP-43 inclusions and pMLKL-positive GVD. This eventually leads to neurodegeneration and neuronal loss