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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease

Fig. 3

TDP-43 and pTau are co-expressed in necroptosis-positive neurons. Triple labeling immunofluorescence with antibodies against pTDP-43 (S409/S410), pTau (S202/T205) and pMLKL (S358) in the CA1 sub-hippocampal field of an ADTDP+ case. Nuclei are stained with Hoechst solution. Of note, a pTDP-43 and pMLKL are co-localized in some GVD granules (arrows) and b pTDP-43 and pTau co-localize in nearby neurons (arrowheads). We exclude the signal observed being considered as unspecific lipofuscin because such signal usually shows in the blue (Hoeschst) channel as orange granules, which in this case is absent

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