Table 2 Associations of lymphatic endothelial cell (LEC) marker scores and presence of lymphatic vessels in the saccular intracranial aneurysm (sIA) walls with sIA-related variables
From: Lymphatic vessels are present in human saccular intracranial aneurysms
LEC marker scores** | Presence of lymphatic vessels | |||||||
|---|---|---|---|---|---|---|---|---|
Variable* | LYVE-1 | Podoplanin | Prox1 | LYVE-1 | Podoplanin | Prox1 | VEGFR-3 | Any LEC+ vessels |
Clinical variables | ||||||||
Sex† | NS | NS | NS | NS | NS | NS | NS | NS |
Smoking, current† | NS | NS | NS | NS | NS | NS | 0.027 | NS |
Presence of multiple IAs† | 0.012 | 0.031 | NS | NS | NS | NS | 0.002 | NS |
Characteristics of the sIA wall | ||||||||
Rupture† | NS | NS | NS | 0.042 | NS | NS | NS | NS |
Wall type† | NS | NS | NS | NS | NS | NS | NS | NS |
Presence of thrombus† | NS | NS | NS | 0.010 | 0.041 | NS | 0.010 | NS |
Area of thrombus‡ | 0.025 | NS | NS | NS | NS | NS | NS | NS |
Presence of CD34 + or CD31 + neovessels† | NS | NS | NS | NS | NS | NS | NS | 0.011 |
Presence of cells in the sIA wall § | ||||||||
Mast cells‡ | NS | NS | NS | NS | NS | 0.031 | NS | NS |
CD3 + T lymphocytes‡ | NS | NS | NS | NS | NS | NS | NS | NS |
CD68 + macrophages‡ | NS | NS | NS | NS | NS | 0.030 | NS | 0.030 |
CD163 + macrophages‡ | 0,046 | 0,045 | NS | NS | NS | NS | 0.033 | NS |
Red blood cells† | NS | NS | 0.003 | NS | NS | 0.003 | 0.028 | NS |
Presence of inflammatory markers in the sIA wall | ||||||||
SAA accumulation† | NS | NS | 0.009 | 0.013 | NS | 0.009 | 0.018 | 0.036 |
MPO expression † | NS | NS | 0.020 | 0.008 | 0.032 | 0.012 | 0.030 | 0.043 |
COX2 expression † | NS | NS | NS | NS | NS | NS | 0.015 | NS |
MMP-9 expression † | NS | 0.021 | NS | NS | NS | NS | NS | NS |
Area (%) of lipid accumulation markers in the sIA wall | ||||||||
ORO+ ‡ | NS | NS | NS | NS | NS | NS | NS | NS |
ApoA-1+ ‡ | NS | NS | 0.002 | NS | NS | NS | NS | NS |
oxLDL+ ‡ | NS | NS | 0.018 | 0.049 | NS | 0.031 | NS | NS |
Adipophilin+ ‡ | NS | NS | NS | NS | NS | NS | NS | NS |