Fig. 2

Sankey plot illustrating original histopathological diagnosis (left) for 43 children registered with ependymoma and corresponding tumor methylation class (right). CPS, cancer predisposition syndrome; ANA-EPN, ependymoma WHO 3; EPN, ependymoma WHO 2; MYX-EPN, myxopapillary ependymoma WHO 2; GBM, atypical glioblastoma with several differential diagnoses considered; where clinical methylation profiling resulted in alteration of the diagnosis; EBLASTOMA, ependymoblastoma incorrectly registered in the Danish Childhood Cancer Registry as ependymoma; NA, not available