Fig. 7

PD0325901 treatment induces apoptosis and decreases cell proliferation in iNPC-LGGs a and b TUNEL⁺ cells are increased (apoptotic cells; green; a), while Ki67⁺ cells are decreased (proliferating cells; green; b), in NF1^−/− iNPC-derived LGGs following PD0325901 treatment. Human tumor cells are Ku80⁺ (red; b). The % area occupied by the iNPC-LGGs is indicated within the images. Data are represented as means ± SEM, two-tailed student’s t-test; Individual p values are indicated within each graph. Scale bars, 50 µm