Table 1 Clinical characteristics of glaucoma and control donors
From: Widespread retina and optic nerve neuroinflammation in enucleated eyes from glaucoma patients
Sample ID | Eye | Condition | Sex | Age at enucleation (years) | Year of enucleation | Visual acuity (BCVA) | IOP (mmHg) | Years with glaucoma diagnosis |
|---|---|---|---|---|---|---|---|---|
E0152-06 | R | Glaucoma (unspecified) | F | 87 | 2006 | Amaurosis | 57 | 23 |
E0554-05 | R | Glaucoma (PEX) | F | 82 | 2005 | Amaurosis | 50 | 13 |
E0048-04 | R | Glaucoma (PEX) | F | 86 | 2004 | Amaurosis | 48 | ~ 30 |
E0568-04 | L | Glaucoma (neovascular) | F | 77 | 2004 | Amaurosis | 50 | Unknown |
E0472-03 | L | Glaucoma (unspecified) | F | 73 | 2003 | Amaurosis | 25 | Unknown |
E0281-04 | L | Glaucoma (POAG) | F | 89 | 2004 | Amaurosis | Last IOP not recorded | Unknown |
E0469-04 | R | Glaucoma (unspecified) | F | 56 | 2004 | Amaurosis | Last IOP not recorded | Unknown |
E0599-02 | R | Glaucoma (unknown) | M | 34 | 2003 | Amaurosis | Last IOP not recorded | Unknown |
E0245-07 | R | Control | M | 86 | 2007 | 0.2 | 13 | NA |
E0029-06 | L | Control | M | 71 | 2006 | NA | 12 | NA |
E0300-06 | R | Control | F | 71 | 2006 | 0.1 | 14 | NA |
E0258-05 | L | Control | F | 67 | 2005 | 1 | 14 | NA |
E0330-05 | R | Control | M | 85 | 2005 | 0.2 | 12 | NA |
E0024-04 | R | Control | M | 61 | 2004 | 0.3 | 10 | NA |
E0271-02 | R | Control | F | 69 | 2002 | 1 | 17 | NA |
E0169-01 | L | Control | M | 72 | 2001 | 0.2 | 11 | NA |
E0214-01 | R | Control | F | 77 | 2001 | HR | 23 | NA |
E0588-01 | R | Control | F | 66 | 2001 | FC 3 m | 16 | NA |
E0001-00 | R | Control | F | 87 | 2000 | Not recorded | Not recorded | NA |
E0471-00 | Unknown | Control | M | 61 | 2000 | R: 0,8 L: 1,0 | Right: 16 Left: 17 | NA |
Sample ID | Medications | Other diseases | Optic Nerve Status at Enucleation | Chamber angle/Iris Status at Enucleation |
|---|---|---|---|---|
E0152-06 | Cyanocobalamin (Vitamin B). Acetylsalicylic acid (Trombocyte aggregation inhibitor). Furosemid (Loop-diuretic). Risperidone (Neurolepticum). Alprazolam (Benzodiazepine). Zopiclone (pyrazolopyrimidine). Propiomazin. Citalopram (SSRI). Mirtazapine (anti-depressive). Donepezil (Cholinesterase inhibitor). Lactulos (Laxitive). Hydroxizin. Paraffin, vaselin (Oculentum simplex) | Hypertension. Depression | Excavation and atrophy | Atrophy. Neovascularization. Occluded chamber angle |
E0554-05 | Pravastatin (Statin). Sotalol (Beta receptor blocker). Klopidogrel (Trombocyte aggregation inhibitor). Digoxin. Furosemid (Loop diuretic). Nitroglycerin. Indometacin (NSAID). Lansoprazole (Proton pump inhibitor). Lactitol (laxative) | Previous gall bladder operation. Hysterectomy and removal of ovaries. Heart infarction 1995. Angina. Heart failure. Cataract | Excavation and atrophy | Neovasculation. Mostly occluded chamber angle |
E0048-04 | Diabetes medication. Irbesartan (Angiotensin II antagonist). Furosemid (Loop diuretic). Verapamil (Calcium antagonist). Digoxin. Allopurinol (xanthine oxidase inhibitor). Anastrozole (Nonsteroidal aromatase inhibitor). Diclofenac (NSAID). Propiomazine (phenothiazines) | Diabetes Type II. Hypertension. Gout. Breat cancer operstion in 2003 | Excavation and atrophy | Atrophy. Synechiae and neovascularization of chamber angle |
E0568-04 | Glibenclamide (Sulfonylurea). Candesartan (angiotensin receptor antaonist). Paracetamol (Acetaminophen). C-vitamin. Estradiol (Estrogen). Insulin (Actrapid, Mixtard, and Insulatard) | Neovascular glaucoma. Previous cholecystectomy. Hypertension. Diabetes. Mild dementia. Incontinence | Excavation and atrophy | Anterior synechiae. Neovascularization of chamber angle |
E0472-03 | Latanoprost (Prostaglandin analog). Timolol (beta blocker). Estradiol, Norethisterone (Estrogen, Progestin) | Glaucoma and cataract left eye for several years. Otherwise healthy | Excavation and atrophy | Chamber anlge partially occluded with anterior synechiae and neovascularization. Some iris neovascularization |
E0281-04 | Unknown | No other diseases recorded | Significant papillary excavation. Neovascularization and atrophy of opticus | Atrophy with neovascularization of iris and neovascularization of chamber angle |
E0469-04 | Unknown | Macular degeneration. Cataract | Excavation and atrophy | Some atrophy. Open chamber angle. No neovascularization |
E0599-02 | Unknown | Chronic uveitis | Excavation and atrophy | Atrophy. Occluded chamber anlge with anterior synechiae and neovascularization |
E0245-07 | Bendroflumethiazide, Potassium chloride (Diuretic, electrolyte). Enalapril (ACE inhibitor). Atorvastatin (statin). Acetylsalicylic acid (Trombocyte aggregation inhibitor). Nitroglycerin | Operated prostate in 1983. Hypertension. Heart infarction in 2004. Angina | No atrophy | Normal for age |
E0029-06 | Enalapril (ACE inhibitor). Felodipine (Calcium antagonist). Bendroflumethiazide, Potassium chloride (Diuretic, electrolyte). Acetylsalicylic acid (Trombocyte aggregation inhibitor) | Operated prostate in 1997. Hip surgery for left hip × 2 with most recent surgery in 2004. Knee surgery for right knee in 2003. Stroke in 2003, since then hemiparesis with partiall recovery | No atrophy | Tumor invasion. Chamber angle partially occluded by tumor |
E0300-06 | Levothyroxine (thyroid hormone). Losartan (Angiotensin II receptor antagonist).Furosemid (Loop diuretic). Cyanocobalamin (Vitamin B). Estradiol (Estragen). Amlodipine (Calcium antagonist) | No other diseases recorded | No atrophy | Tumor invasion |
E0258-05 | Amlodipine (Calcium antagonist). Ranitidine (Anti-histamine) | Hypertension | No atrophy | Normal for age |
E0330-05 | Diclofenac (NSAID) | Previously operated × 3 for kidney stones. Gout | No atrophy | Normal for age |
E0024-04 | No medications | Appendectomized | No atrophy | Tumor invasion of the iris |
E0271-02 | No medications | Healthy. Was admitted to a hospital many years prior due to a benign gynecological event | No atrophy | Normal for age |
E0169-01 | No medications | Previously operated for mitralis insufficiency in April 2000 with plastic ring. Pacemaker since fall 2000 | No atrophy | Normal for age |
E0214-01 | No medications | Healthy. No previous operations | No atrophy | NA |
E0588-01 | Amitriptylin (tricyclic antidepressant). Atenolol (Beta receptor blocker). Estradiol (Estrogen) | Recurring depression | No atrophy | Tumor invasion |
E0001-00 | Unknown | No other diseases recorded | No atrophy | Normal for age |
E0471-00 | No medications | Previously healthy | No atrophy | Normal for age |