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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variants

Fig. 3

Antiviral and inflammatory responses in the olfactory bulb, cerebral cortex and cerebellum of SARS-CoV-2 infected hamsters. Expression of several genes important for interferon responses, for recruitment of microglia/macrophages and T-cells and chemokines were determined with reverse transcriptase quantitative PCR in the A olfactory bulb, B cerebral cortex and C cerebellum. The data displayed represent four animals per group. Statistical significance was calculated with a One-Way analysis of variance (ANOVA) with a Dunnett’s posthoc test. Averaged values of four individual animals per infection group were compared to values of four mock treated animals. Asterisks indicate statistical significance*, P < 0.05, **, P < 0.01, ***P < 0.001, ****P > 0.0001). Ifnb, interferon-β; Ifnl, interferon-λ; Mx2, interferon-induced GTP-binding protein; Aif1/Iba-1 allograft inflammatory factor 1 Aif1 encoding the protein ionized calcium-binding adapter molecule 1 (IBA-1); Cd3, cluster of differentiation; Cxcl10, C-X-C motif chemokine 10; CCL5 C–C motif chemokine ligand 5 (Ccl5)

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