Interpretable deep learning of myelin histopathology in age-related cognitive impairment

Table 1 Description of cohort subset and whole slide image dataset used in this study

Category	Non-cognitively impaired	Cognitively impaired	Total group	p-value for difference*
Sample size	367	349	716	Not applicable
Age (Mean ± SEM)	83.0 ± 0.58	87.4 ± 0.48	85.2 ± 0.39	p = 1.02 * 10^–8
Proportion female	0.54	0.53	0.54	Not significant
Mean Braak score	2.4	2.5	2.4	Not significant
Proportion CERAD neuropathology positive	0.15	0.18	0.17	Not significant
Proportion hippocampal ARTAG positive	0.22	0.31	0.27	p = 0.015
Proportion with hippocampal WSI	0.99	0.99	0.99	Not significant
Proportion with frontal WSI	0.46	0.46	0.46	Not significant

This table describes the pathoclinical characteristics of the subset of brain donors employed in this study. The significance of differences in categorical variables between the non-cognitively impaired and cognitively impaired groups was assessed with a two-proportions z-test, while the significance of differences in numerical variables was assessed with a t-test. WSI = Whole slide image; SEM = Standard error of the mean; ARTAG = Aging-Related Tau Astrogliopathy; CERAD = Consortium to Establish a Registry for Alzheimer's Disease