Fig. 6
From: Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s
Mitochondrial analysis of label free proteomic data. Oxidative phosphorylation pathway diagram with per region overlay of proteomic expression for the putamen and frontal cortex in early PD compared to controls, a and late PD compared to controls, e. Red represents upregulation and green represents downregulation. Intensity of colour indicates level of altered expression. b, f Complex proteins totalled and ratioed to citrate synthase across brain regions and disease stages. Two-way ANOVA with Sidek’s multiple comparison post-hoc testing was performed for each complex/citrate synthase and statistically significant results are demonstrated on graphs with * representing p < 0.03, ** representing p < 0.002, *** representing p < 0.0002 and **** representing p < 0.0001. Bars represent SEM. c, g Table indicating the % of significantly altered proteins per pathway for the sub-functions of the mitochondria as determined through Mitominer and Panther. Regions are colour-coded for severity of pathology present at that stage of disease as shown in key. d HADHB and ACAT1 expression across multiple brain regions, Graphs and statistics were completed using GraphPad Prism v8