Skip to main content
Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Glioblastoma CD105+ cells define a SOX2 cancer stem cell-like subpopulation in the pre-invasive niche

Fig. 7

Schematic illustrating multiple roles of CD105+ cells in GBM. A CD105+ cell interacts with the TGF-β pathway. CD105, a receptor of TGF-β, can affect angiogenesis, vascular permeability and cell proliferation by binding different TGF-β subtypes. B, C CD105+ cell shapes the tumor immunosuppressive microenvironment. Cytokines secreted by GBM CD105+ cells share the function of recruiting immunosuppressive cells. CD105+ cells impair immune cell function and contribute to creating an immunosuppressive barrier. D CD105 constitute a marker of GBM vasculature. E In vitro drug sensitivity screening of CD105+ cells. CD105+ cells are resistant to conventional drugs: TMZ and AVZ but sensitive to ABT-751, Doxorubicin, Idarubicin and Fludarabine. F Schematic depicts the “Seed and soil” rational for GBM growth. Based on the distribution and function of CD105+ cells, we predict CD105+ cells may release extracellular matrix (ECM), initiating a tumor tolerant microenvironment and thereby promoting tumor progression

Back to article page