Fig. 2

Neuropathological correlates of SOD1, TDP43 and p62 proteinopathies in spinal cord motor neurons of post-mortem ALS and control cases. Quantitative data describing disordered SOD1 (DisSOD1) pathology, neuronal loss and the proportion of motor neurons exhibiting DisSOD1 mislocalization in the spinal cord of our post-mortem tissue cohort are published in a related article [47]. Spearman’s r coefficient (top) and the p value (bottom) of each correlation are stated within panel. Positive and negative Spearman’s r coefficients are delineated by a binary colour gradient. n = 33–35 data points for each correlation. A correlation is considered to be strong if Spearman’s r = 0.5 or higher. Asterisks indicate statistically significant correlations