Fig. 8
From: BDNF-dependent modulation of axonal transport is selectively impaired in ALS
Schematic summarising the key findings from this study. In wild-type (WT) mice, retrograde signalling endosome speeds are similar between fast motor neurons (MNs) and slow MNs. BDNF stimulation increases signalling endosome speeds only in fast MNs. In SOD1G93A mice, fast MNs display deficits in axonal transport and are refractory to BDNF stimulation, whereas axonal transport is unperturbed in slow MNs. Refractiveness to BDNF stimulation is also found in ventral horn spinal cord cultures isolated from SOD1G93A mice. In adult WT mice, BDNF levels are higher in tibialis anterior (TA) than soleus muscles, and TrkB and p75NTR levels are equivalent at the neuromuscular junction (NMJ). However, truncated TrkB and p75NTR levels are increased in SOD1G93A muscles and sciatic nerves, but not at the NMJ or in primary ventral horn neurons. Green upward arrows indicate an enhancement, whereas orange downward arrows highlight a negative effect. The symbol ≈ indicates no difference. Figure created with BioRender (https://biorender.com)