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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: BDNF-dependent modulation of axonal transport is selectively impaired in ALS

Fig. 7

TrkB.T1 and p75NTR are increased in SOD1G93A sciatic nerves. A Immunoblots of TrkB.T1, p75NTR, p-ERK1/2, ERK1/2, and cofilin in WT and SOD1G93A sciatic nerves. N.B. TrkB.FL levels were below detection. Quantification: B TrkB.T1 (**p = 0.007); C) p75NTR (***p < 0.001); and D p-ERK1/2-ERK1/2 ratio (p = 0.948), by unpaired, two-tailed t-tests (n = 10). Black (P73) and grey (P94) circles indicate age-matched mice. Immunostaining of: E TrkB; and F p75NTR in axons (TUJ1) and Schwann cells (S100). White and yellow arrowheads identify TrkB/p75NTR staining in TUJ1 and S100 regions, respectively. Scale bar = 25 µm. Immunostaining quantification: G TrkB (genotype p = 0.204, cell type p = 0.239, interaction p = 0.384); and H p75.NTR (genotype *p = 0.018, cell type p = 0.053, interaction p = 0.204). Levels in axons or Schwann cells, as assessed by two-way ANOVA and Holm-Šídák's multiple comparisons tests (n = 4). Means ± SEM are plotted for all graphs. *p < 0.05, **p < 0.01, ***p < 0.001

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