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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: BDNF-dependent modulation of axonal transport is selectively impaired in ALS

Fig. 4

Retrograde transport and BDNF response are selectively impaired in tibialis anterior (TA) motor axons in SOD1G93A mice. Retrograde transport in motor axons innervating TA in early (P73) and symptomatic (P94) SOD1G93A mice compared to wild type (WT) mice, displaying: A endosome frame-to-frame speed distribution curves, B average and maximum endosome speeds (average: **p = 0.004; maximum: **p = 0.001; one-way ANOVA, n = 5–7), and the C) relative percentage of time signalling endosomes paused in TA-innervating axons (p = 0.061; one-way ANOVA, n = 5–7). Retrograde axonal transport in motor axons innervating soleus in early and symptomatic SOD1G93A mice compared to WT mice displaying: D endosome frame-to-frame speed distribution curves, E average and maximum endosome speeds (average: p = 0.28; maximum: p = 0.326; one-way ANOVA, n = 5–7), and F relative percentage of time signalling endosomes paused in soleus-innervating axons (p = 0.562; one-way ANOVA, n = 6). Axonal endosome transport in P73 and P94 SOD1G93A TA-innervating axons with and without BDNF stimulation, displaying: G endosome frame-to-frame speed distribution curves, H average and maximum endosome speeds (average: p = 0.464; maximum: p = 0.102; one-way ANOVA, n = 6) and I relative percentage of time signalling endosomes paused in TA-innervating axons with or without intramuscular BDNF stimulation (p = 0.521, one-way ANOVA, n = 6). Axonal endosome transport in P73 and P94 SOD1.G93A vs. WT mice upon intramuscular BDNF application in motor axons innervating TA, displaying: J endosome frame-to-frame speed distribution curves, K average and maximum endosome speeds (average: ***p < 0.001; maximum: ***p < 0.001; one-way ANOVA, n = 6–8), and L relative percentage of time signalling endosomes paused (***p < 0.001). Means ± SEM are plotted for all graphs. *p < 0.05, **p < 0.01, Kruskal–Wallis multiple comparisons test. See also Additional file 2: Figs. S3 and S4 and Table S1

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