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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease

Fig. 5

Single-cell RNA-seq reveals the complexity of microglial response to amyloid pathology. A UMAP embedding representation of 6,202 single-cells harvested from cortices and hippocampi of 15-month-old female Tg2576 and wild type mice. UMAP is annotated by clusters of major subpopulations recovered. B Distribution of the expression of signature homeostatic microglial genes Csf1r and Tmem119 and disease-associated microglial genes Cst7 and Lpl. C Gene ontology (GO) analyses of top 50 genes enriched in microglial and perivascular macrophage clusters. D Violin plot displays the expression levels of Aif1 (Iba1, left panel) and Itgax (Cd11c, right panel) per subpopulation

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Acta Neuropathologica Communications

ISSN: 2051-5960

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