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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Sporadic Creutzfeldt-Jakob disease VM1: phenotypic and molecular characterization of a novel subtype of human prion disease

Fig. 4

Evidence of CJD V2 features in the brainstem of patient #5. Small plaque-like PrP deposits in the substantia nigra (A) and midbrain periacqueductal gray (B) (immunohistochemistry for PrP with the mAb 3F4). C Western blot (mAb 3F4) shows the co-occurrence of PrPSc type 1 (unglycosylated band migrating at 21 kDa) and 2 (at 19 kDa) in multiple brainstem areas (MDB, midbrain; PNS, pons; ME medulla). Ctrl = control

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