Fig. 5
From: Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice
Aβ and tau pathologies in the perirhinal/entorhinal cortex following ADbe inoculation in APPswe/PS1dE9 mice (8 mpi). Representative images of the 4G8 immunolabelling showing Aβ pathology (a) and the AT8 immunolabelling showing tau pathology (b) in Ctrlbe- and ADbe-inoculated APPswe/PS1dE9 mice. Magnified views of Aβ (c, d) and tau (f, g) lesions in the perirhinal/entorhinal cortex. Quantification of Aβ load (e, p > 0.05), overall AT8-positive tau lesions (h, p < 0.0001), neuritic plaque (NPs) count (i, p = 0.0098), AT8-positive area stained within neuritic plaques (j, p < 0.0001), neuropil threads (NTs—k, p < 0.0001), and NFTs (l, p < 0.0001) in the perirhinal/entorhinal cortex. Mann Whitney's tests. **p < 0.01; ****p < 0.0001. nCtrl = 15, nAD1 = 15 (light pink), nAD2 = 20 mice (dark pink). Data are shown as mean ± s.e.m. Scale bars = 500 µm (a, b), 100 µm (c, d, f, g) and 20 µm in inset