Table 2 Generalized Linear Model fitted with Gamma distribution and log link depicting average CA density by Braak stage, controlling for age, PMI, APOE allele, cognitive status, and sex
From: Corpora amylacea are associated with tau burden and cognitive status in Alzheimer’s disease
Characteristic | Ratio of means | 95% CIa | p-value |
|---|---|---|---|
Braak stage (I–VI) | 0.006 | ||
I | – | – | |
II | 1.72 | 0.73, 3.90 | 0.2 |
III | 2.13 | 0.79, 5.69 | 0.11 |
IV | 0.65 | 0.24, 1.70 | 0.4 |
V | 0.52 | 0.19, 1.38 | 0.2 |
VI | 0.64 | 0.25, 1.52 | 0.3 |
Age (years) | 1.01 | 0.99, 1.03 | 0.3 |
PMI (minutes) | 1.00 | 1.00, 1.00 | 0.4 |
APOE allele (grouped) | 0.13 | ||
E23/E33 | – | – | |
E34/E44 | 0.67 | 0.41, 1.13 | 0.13 |
Cognitive status | 0.4 | ||
Cognitively normal | – | – | |
Mild impairment | 1.70 | 0.64, 5.28 | 0.3 |
Dementia | 1.59 | 0.80, 3.15 | 0.2 |
Sex | > 0.9 | ||
F | – | – | |
M | 1.01 | 0.64, 1.59 | > 0.9 |