Fig. 5
From: Corpora amylacea are associated with tau burden and cognitive status in Alzheimer’s disease
Dentate CA depletion is associated with APOE E4 status and cognitive decline. Schematic describing correlation between Braak stage and CA decline in the DG. CA accumulate in the dentate gyrus hilus proximal to the hippocampal sulcus, where they are extruded via the glia limitans. CA harbor Tau-1-immunoreactive hypophosphorylated (not hyperphosphorylated) tau that may be released into the CSF. In both mouse models of AD risk and tauopathy, PAS granule density is elevated (asterisks denote single time-point assessments of PAS granule density from this study). In humans, CA levels (as determined by CA/mm2) are reduced in dementia patients and APOE E4 carriers at critical tau-seeding Braak stages when compared to cognitively normal or APOE E4 non-carriers, respectively. Our model is consistent with the hypothesis that CA are protective against the accumulation of AD pathology but become exhausted with increasing neuropathological burden in human brain