Evidence of cerebellar TDP-43 loss of function in FTLD-TDP

Table 3 Associations of cerebellar TDP-43 with tSTMN2 RNA, age at onset, and disease duration in FTLD-TDP cases

Variable	N	Unadjusted analysis		Multivariable analyses
Variable	N	β (95% CI)	P-value	β (95% CI)	P-value	Multivariable model adjustments
tSTMN2 RNA	95	− 0.2604 (− 0.3621 to − 0.1588)	< 0.0001	− 0.2078 (− 0.3136 to − 0.1021)	0.0002	Age, sex, and genotype
Age at onset (years)	85	0.02175 (0.009906 to 0.03359)	0.0005	0.01624 (0.003352 to 0.02912)	0.0142	Sex and genotype
Disease duration (years)	85	0.02088 (− 0.003103 to 0.04487)	0.0871	0.02693 (0.004536 to 0.04932)	0.0190	Sex, age at onset and genotype

β = regression coefficient; CI = confidence interval. β values, 95% CIs and p-values are shown for associations of TDP-43 with the indicated variables from unadjusted linear regression models or linear regression models adjusted for indicated variable. P-values < 0.0167 are considered statistically significant after correcting for multiple comparisons and are marked in bold

ISSN: 2051-5960