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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Evidence of cerebellar TDP-43 loss of function in FTLD-TDP

Fig. 1

Truncated STMN2 RNA is elevated, and soluble TDP-43 protein is decreased in the cerebellum of FTLD-TDP cases. A, B tSTMN2 RNA and TDP-43 protein levels were measured in FTLD-TDP cases (n = 95) and non-neurological disease controls (n = 25). A tSTMN2 RNA levels, as measured by NanoString PlexSet platform, are significantly elevated in FTLD-TDP cases. B Soluble TDP-43 protein levels, as quantified from Western blot, are significantly decreased in FTLD-TDP cases. Horizontal bars represent mean 95% confidence intervals (95% CI). P-values and 95% CI from unadjusted linear regression models are shown. Note values for linear regression models adjusted for age, sex and RIN are shown in Table 2. C Associations of TDP-43 protein levels with tSTMN2 RNA levels were examined in FTLD-TDP cases. Regression coefficient (β), 95% CI and P-values from unadjusted linear regression models are shown. Values for linear regression models adjusted for age, sex and genotype are shown in Table 3. D, E TDP-43 protein levels in the cerebellum of FTLD-TDP cases (n = 8) and controls (n = 10) were measured by western blot in the RIPA-soluble (D) and RIPA-insoluble (E) fractions. A representative western-blot (above) and densiometric quantification (below) are presented. Data are presented as mean + / − SEM. P values shown resulting from Mann Whitney test

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