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Table 1 Changes/refinements in PAD or methylation class between the primary and relapse tumour

From: DNA methylation alterations across time and space in paediatric brain tumours

Patient ID

Primary PAD

Relapse PAD

Primary methylation class

Relapse methylation class

pTT-6

PA grade I

DLGNT

Supratentorial midline PA (0.74)

Supratentorial midline PA (0.82)

pTT-9

Malignant glioneural tumour

Anaplastic EPN grade III

Supratentorial EPN, ZFTA:RELA fusion-positive (0.99)

Supratentorial EPN, ZFTA:RELA fusion-positive (0.99)

pTT-19

Ganglioglioma

Ganglioglioma

Supratentorial PA (0.24)

Ganglioglioma (0.92)

pTT-21

PA grade I

Malignant high-grade tumour

Neuroepithelial tumour with PATZ1 fusion (0.99)

Neuroepithelial tumour with PATZ1 fusion (0.97)

pTT-23

High-grade primitive tumour

Malignant-high grade tumour

No class

No class

pTT-28

PA grade I

PA grade I

Supratentorial midline PA (0.71)

PXA(-like) (0.98)

pTT-32

Glioblastoma

Malignant high-grade tumour

Diffuse paediatric-type high grade glioma, MYCN subtype (0.11)

Supratentorial EPN, ZFTA:RELA fusion-positive (0.26)

  1. The number in parenthesis states the calibrated score of the methylation classification. PAD Pathological anatomical diagnosis, PA Pilocytic astrocytoma, DLGNT Diffuse leptomeningeal glioneuronal tumour, EPN Ependymoma, PXA Pleomorphic xanthoastrocytoma