Fig. 2

Methylation-based superfamily classification is robust for spatial and temporal paediatric brain tumours. A All samples were classified with the MNP classifier v12.5 and the calibrated classification score (≥ 0.9 is a successful classification; indicated by dashed line) is visualised on the y-axis for each spatial and B temporal sample. The samples are grouped according to their patient identity (x-axis) and coloured according to their best-predicted methylation superfamily. C The tumour cell content (y-axis) for spatial and D temporal samples. A red X denotes that the sample was excluded from further analysis. The legend applies to all subfigures