Fig. 1

Experimental setup and patient cohort. A Children operated for a brain tumour were included in this study. We either sampled 3–7 spatially separated biopsies from the same tumour (left), or one biopsy from a primary tumour and one biopsy from the paired relapse tumour (right). All samples were processed on Infinium EPIC BeadChip methylation arrays and classified with the MNP classifier v12.5. B The pathological-anatomical diagnosis for the 11 patients in the spatial study setting, and C primary tumour of the 35 patients in the paired primary-relapse setting. AT/RT Atypical teratoid rhabdoid tumour, NOS Not otherwise specified, PXA Pleomorphic xanthoastrocytoma