Fig. 5

Ultrastructure of the nuclei. Electron microscopy detected nuclear anomalies in the muscle samples including intranuclear rods in patients 5 and 7 (B, C), and especially a significant enlargement of the perinuclear space scaling up to 165 nm in patient 5 (B), 195 nm in patient 1 (A), 217 nm in patient 4 (E), 230 nm in patient 11 (F), 390 nm in patient 7 (D), and 1230 nm in patient 6 (C) as indicated by the red bars. Patient 1 additionally displayed dense heterochromatic areas (A)