Fig. 4From: Severe ACTA1-related nemaline myopathy: intranuclear rods, cytoplasmic bodies, and enlarged perinuclear space as characteristic pathological features on muscle biopsiesCytoplasmic bodies by electron microscopy. Cytoplasmic bodies showing the characteristic halo of radiating filaments as illustrated on muscle sections from patients 4, 5, 8, and 9 (arrows, A–D). The patients also displayed fibre size variability, myofibre disorganization and endomysial fibrosis. The enlargement of the perinuclear space is indicated in patient 9 (arrow, D)Back to article page