Mitochondrial DNA Haplogroup | Haplogroup frequency, No. (%), N = 242 | Association with dorsolateral putaminal TH−ir | Association with ventromedial putaminal TH−ir | Association with ventrolateral substantia nigra neuronal loss score | Association with medial substantia nigra neuronal loss score | ||||
---|---|---|---|---|---|---|---|---|---|
Regression coefficient (95% CI) | P−value | Regression coefficient (95% CI) | P−value | OR (95% CI) | P-value | OR (95% CI) | P-value | ||
Na | 0 (0.0%) | – | – | – | – | – | – | – | – |
N1a | 0 (0.0%) | – | – | – | – | – | – | – | – |
Ia | 8 (3.3%) | – | – | – | – | – | – | – | – |
Wa | 2 (0.8%) | – | – | – | – | – | – | – | – |
Xa | 4 (1.7%) | – | – | – | – | – | – | – | – |
R and R0a | 1 (0.4%) | – | – | – | – | – | – | – | – |
HV and HV0aa | 8 (3.3%) | – | – | – | – | – | – | – | – |
H, H1, H2, H3 and H4 | 91 (37.6%) | −0.05 (−0.15, 0.05) | 0.32 | −0.11 (−0.40, 0.18) | 0.45 | 0.80 (0.43, 1.46) | 0.46 | 1.12 (0.63, 1.97) | 0.70 |
H | 40 (16.5%) | 0.05 (−0.09, 0.18) | 0.51 | 0.11 (−0.27, 0.49) | 0.55 | 0.44 (0.21, 0.93) | 0.033 | 0.54 (0.26, 1.10) | 0.090 |
H1 | 27 (11.2%) | −0.07 (−0.23, 0.09) | 0.42 | −0.13 (−0.58, 0.32) | 0.57 | 1.33 (0.48, 3.68) | 0.58 | 1.28 (0.52, 3.13) | 0.59 |
H2a | 8 (3.3%) | – | – | – | – | – | – | – | – |
H3a | 12 (5.0%) | −0.04 (−0.26, 0.19) | 0.75 | −0.29 (−0.92, 0.34) | 0.36 | 0.90 (0.25, 3.31) | 0.88 | – | – |
H4a | 4 (1.7%) | – | – | – | – | – | – | – | – |
Va | 8 (3.3%) | – | – | – | – | – | – | – | – |
JTa | 0 (0.0%) | – | – | – | – | – | – | – | – |
J, J1, J1d, J2a and J2b | 26 (10.7%) | 0.06 (−0.09, 0.21) | 0.42 | 0.05 (−0.37, 0.47) | 0.81 | 0.87 (0.36, 2.09) | 0.75 | 0.62 (0.28, 1.39) | 0.25 |
Ja | 0 (0.0%) | – | – | – | – | – | – | – | – |
J1 | 23 (9.5%) | 0.07 (−0.09, 0.22) | 0.39 | 0.06 (−0.38, 0.50) | 0.78 | 0.93 (0.37, 2.33) | 0.87 | 0.72 (0.31, 1.69) | 0.46 |
J1ad | 0 (0.0%) | – | – | – | – | – | – | – | – |
J2aa | 2 (0.8%) | – | – | – | – | – | – | – | – |
J2ba | 1 (0.4%) | – | – | – | – | – | – | – | – |
T, T1 and T2 | 30 (12.4%) | −0.03 (−0.19, 0.13) | 0.70 | −0.07 (−0.52, 0.38) | 0.74 | 1.42 (0.49, 4.11) | 0.52 | 2.60 (0.87, 7.81) | 0.088 |
T1 | 0 (0.0%) | – | – | – | – | – | – | – | – |
T1a | 4 (1.7%) | – | – | – | – | – | – | – | – |
T2 | 26 (10.7%) | 0.02 (−0.15, 0.19) | 0.82 | 0.14 (−0.35, 0.63) | 0.58 | 1.35 (0.42, 4.30) | 0.62 | 2.52 (0.72, 8.80) | 0.15 |
U, U1, U3, U5, U6 and U8b'c | 41 (16.9%) | −0.05 (−0.18, 0.08) | 0.47 | −0.15 (−0.53, 0.23) | 0.44 | 1.75 (0.72, 4.24) | 0.21 | 1.21 (0.57, 2.55) | 0.62 |
U1 | 12 (5.0%) | – | – | – | – | – | – | – | – |
U1a | 2 (0.8%) | – | – | – | – | – | – | – | – |
U3a | 1 (0.4%) | – | – | – | – | – | – | – | – |
U5 | 25 (10.3%) | −0.04 (−0.20, 0.12) | 0.66 | −0.17 (−0.62, 0.28) | 0.45 | 1.59 (0.56, 4.51) | 0.39 | 1.41 (0.56, 3.53) | 0.47 |
U6a | 0 (0.0%) | – | – | – | – | – | – | – | – |
U8b'ca | 1 (0.4%) | – | – | – | – | – | – | – | – |
K | 23 (9.5%) | 0.00 (−0.18, 0.17) | 0.98 | 0.04 (−0.45, 0.54) | 0.87 | 0.60 (0.23, 1.59) | 0.31 | 1.29 (0.49, 3.39) | 0.61 |