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Table 2 Associations between mitochondrial DNA haplogroups and risk of DLB

From: Mitochondrial genomic variation in dementia with Lewy bodies: association with disease risk and neuropathological measures

Mitochondrial DNA Haplogroup Haplogroup frequency, No. (%) Clinical DLB vs. controls LBD with a high likelihood of DLB vs. controls Overall DLB vs. controls
Controls (N = 910) Clinical DLB (N = 360) LBD high likelihood of DLB (N = 446) Overall DLB (N = 758) OR (95% CI) P-value OR (95% CI) P-value OR (95% CI) P-value
Na 2 (0.2%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
N1a 5 (0.5%) 4 (1.1%) 2 (0.4%) 6 (0.8%) 1.31 (0.38, 4.49) 0.66
I 31 (3.4%) 12 (3.3%) 13 (2.9%) 22 (2.9%) 0.77 (0.38, 1.56) 0.47 0.83 (0.41, 1.60) 0.60 0.77 (0.44, 1.38) 0.38
W 15 (1.6%) 9 (2.5%) 8 (1.8%) 15 (2.0%) 1.71 (0.69, 4.23) 0.24 1.11 (0.44, 2.64) 0.81 1.30 (0.61, 2.76) 0.50
X 8 (0.9%) 2 (0.6%) 7 (1.6%) 9 (1.2%) 0.60 (0.12, 3.10) 0.55 1.68 (0.57, 4.82) 0.33 1.36 (0.50, 3.69) 0.55
R or R0a 6 (0.7%) 1 (0.3%) 1 (0.2%) 2 (0.3%)
HV or HV0a 22 (2.4%) 6 (1.7%) 13 (2.9%) 17 (2.2%) 0.86 (0.33, 2.26) 0.76 1.36 (0.65, 2.74) 0.40 1.02 (0.53, 2.00) 0.94
H, H1, H2, H3, and H4 423 (46.5%) 149 (41.4%) 183 (41.0%) 316 (41.7%) 0.85 (0.65, 1.10) 0.22 0.83 (0.66, 1.05) 0.13 0.85 (0.70, 1.04) 0.12
H 199 (21.9%) 51 (14.2%) 85 (19.1%) 133 (17.5%) 0.61 (0.43, 0.87) 0.006 0.87 (0.65, 1.16) 0.34 0.78 (0.61, 1.01) 0.057
H1 145 (15.9%) 67 (18.6%) 56 (12.6%) 116 (15.3%) 1.22 (0.87, 1.71) 0.26 0.78 (0.55, 1.09) 0.16 0.97 (0.74, 1.28) 0.85
H2 36 (4.0%) 6 (1.7%) 12 (2.7%) 17 (2.2%) 0.44 (0.18, 1.09) 0.076 0.67 (0.33, 1.28) 0.24 0.56 (0.30, 1.02) 0.057
H3 32 (3.5%) 16 (4.4%) 23 (5.2%) 36 (4.7%) 1.42 (0.73, 2.75) 0.30 1.59 (0.89, 2.78) 0.11 1.48 (0.89, 2.47) 0.13
H4 11 (1.2%) 9 (2.5%) 7 (1.6%) 14 (1.8%) 1.76 (0.70, 4.46) 0.23 1.14 (0.41, 2.98) 0.80 1.33 (0.59, 3.01) 0.50
V 18 (2.0%) 14 (3.9%) 12 (2.7%) 26 (3.4%) 1.99 (0.94, 4.22) 0.073 1.37 (0.63, 2.91) 0.41 1.82 (0.97, 3.42) 0.064
JTa 2 (0.2%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
J, J1, J1d, J2, J2a,
and J2b
93 (10.2%) 38 (10.6%) 52 (11.7%) 87 (11.5%) 1.02 (0.67, 1.55) 0.94 1.13 (0.78, 1.63) 0.51 1.11 (0.81, 1.54) 0.51
J 0 (0.0%) 1 (0.3%) 0 (0.0%) 1 (0.1%)
J1 72 (7.9%) 25 (6.9%) 41 (9.2%) 64 (8.4%) 0.82 (0.50, 1.35) 0.44 1.11 (0.73, 1.67) 0.61 1.02 (0.71, 1.46) 0.93
J1d 1 (0.1%) 1 (0.3%) 0 (0.0%) 1 (0.1%)
J2a 13 (1.4%) 7 (1.9%) 9 (2.0%) 15 (2.0%) 1.80 (0.67, 4.89) 0.25 1.74 (0.70, 4.16) 0.22 1.66 (0.76, 3.62) 0.20
J2b 7 (0.8%) 4 (1.1%) 2 (0.4%) 6 (0.8%) 1.20 (0.32, 4.48) 0.79 0.95 (0.30, 2.95) 0.92
T, T1, and T2 77 (8.5%) 32 (8.9%) 45 (10.1%) 71 (9.4%) 1.16 (0.73, 1.84) 0.53 1.25 (0.84, 1.86) 0.26 1.17 (0.83, 1.67) 0.38
Ta 0 (0.0%) 1 (0.3%) 0 (0.0%) 1 (0.1%)
T1 17 (1.9%) 5 (1.4%) 8 (1.8%) 13 (1.7%) 0.64 (0.22, 1.85) 0.41 0.85 (0.34, 1.96) 0.71 0.83 (0.39, 1.76) 0.62
T2 60 (6.6%) 26 (7.2%) 37 (8.3%) 57 (7.5%) 1.27 (0.76, 2.12) 0.35 1.38 (0.89, 2.14) 0.15 1.25 (0.84, 1.85) 0.26
U, U1, U3, U5, U6, and U8b'c 130 (14.3%) 53 (14.7%) 67 (15.0%) 110 (14.5%) 0.97 (0.67, 1.40) 0.89 1.01 (0.73, 1.40) 0.95 0.96 (0.72, 1.28) 0.79
U 44 (4.8%) 22 (6.1%) 21 (4.7%) 40 (5.3%) 1.12 (0.64, 1.96) 0.68 0.89 (0.51, 1.51) 0.66 0.97 (0.61, 1.52) 0.88
U1a 1 (0.1%) 0 (0.0%) 2 (0.4%) 2 (0.3%)
U3a 8 (0.9%) 0 (0.0%) 1 (0.2%) 1 (0.1%)
U5 74 (8.1%) 30 (8.3%) 42 (9.4%) 65 (8.6%) 0.99 (0.62, 1.59) 0.97 1.13 (0.74, 1.68) 0.57 1.02 (0.71, 1.47) 0.90
U6a 3 (0.3%) 1 (0.3%) 0 (0.0%) 1 (0.1%)
U8b'ca 0 (0.0%) 0 (0.0%) 1 (0.2%) 1 (0.1%)
K 78 (8.6%) 40 (11.1%) 43 (9.6%) 77 (10.2%) 1.23 (0.80, 1.88) 0.35 1.12 (0.74, 1.66) 0.59 1.15 (0.81, 1.62) 0.44
  1. OR = odds ratio; CI = confidence interval. ORs, 95% CIs, and p-values result from logistic regression models that were adjusted for age and sex. The 47 cases that were in both the clinical DLB series and the LBD with a high likelihood of DLB series were included only once in the overall DLB series. After applying a Bonferroni correction for multiple testing, P-values <  0.0023 (clinical DLB vs. controls), <  0.0024 (LBD with a high likelihood of DLB vs. controls), and <  0.0022 (overall DLB vs. controls) were considered as statistically significant.
  2. aHaplogroups that occurred in < 10 subjects in a given association analysis were not examined.