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Table 1 Patient characteristics

From: Mitochondrial genomic variation in dementia with Lewy bodies: association with disease risk and neuropathological measures

Variable Controls (N = 910) Clinical DLB (N = 360) LBD with a high likelihood of DLB (N = 446)
Age (years)a 79 (41, 102) 73 (50, 100) 78 (48, 103)
Sex
Male 388 (42.6%) 270 (75.0%) 292 (65.5%)
Female 522 (57.4%) 90 (25.0%) 154 (34.5%)
Braak NFT stage
0 N/A N/A 13 (2.9%)
I N/A N/A 23 (5.2%)
II N/A N/A 138 (30.9%)
III N/A N/A 143 (32.1%)
IV N/A N/A 129 (28.9%)
V N/A N/A 0 (0.0%)
VI N/A N/A 0 (0.0%)
Thal amyloid phase
0 N/A N/A 40 (10.7%)
1 N/A N/A 37 (9.9%)
2 N/A N/A 23 (6.1%)
3 N/A N/A 129 (34.4%)
4 N/A N/A 56 (14.9%)
5 N/A N/A 90 (24.0%)
LBD subtype
Transitional N/A N/A 89 (20.0%)
Diffuse N/A N/A 357 (80.0%)
Lewy body counts
Middle frontal gyrus N/A N/A 5 (0, 35)
Superior temporal gyrus N/A N/A 10 (0, 50)
Inferior parietal gyrus N/A N/A 4 (0, 30)
Cingulate gyrus N/A N/A 12 (2, 32)
Parahippocampal gyrus N/A N/A 16 (1, 45)
Putaminal TH-ir
Dorsolateral N/A N/A 2.93 (0.26, 21.61)
Ventromedial N/A N/A 8.99 (0.26, 27.42)
Substantia nigra neuronal loss score
Ventrolateral
 0.0 = none N/A N/A 0 (0.0%)
 0.5 = none/mild N/A N/A 2 (1.0%)
 1.0 = mild N/A N/A 10 (5.1%)
 1.5 = mild/moderate N/A N/A 7 (3.6%)
  2.0 = moderate N/A N/A 21 (10.8%)
 2.5 = moderate/severe N/A N/A 23 (11.8%)
 3.0 = severe N/A N/A 132 (67.7%)
Medial    
 0.0 = none N/A N/A 2 (1.1%)
 0.5 = none/mild N/A N/A 1 (0.6%)
 1.0 = mild N/A N/A 25 (14.0%)
 1.5 = mild/moderate N/A N/A 16 (8.9%)
 2.0 = moderate N/A N/A 26 (14.5%)
 2.5 = moderate/severe N/A N/A 25 (14.0%)
 3.0 = severe N/A N/A 84 (46.9%)
  1. Sample median (minimum, maximum) is given for continuous variables
  2. For LBD cases with a high likelihood of DLB, information was unavailable for Thal amyloid phase (N = 71), middle frontal gyrus Lewy body count (N = 211), superior temporal gyrus Lewy body count (N = 213), inferior parietal gyrus Lewy body count (N = 211), cingulate gyrus Lewy body count (N = 213), parahippocampal gyrus Lewy body count (N = 232), dorsolateral putaminal TH-ir (N = 250), ventromedial putaminal TH-ir (N = 250), ventrolateral substantia nigra neuronal loss score (N = 251), and medial substantia nigra neuronal loss score (N = 267).
  3. aAge represents age at blood draw for controls, age at DLB onset for clinical DLB cases, and age at death for LBD with a high likelihood of DLB cases