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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis

Fig. 6

Decorin activates autophagy-associated lysosomal degradation. ac Quantitative western blot of p62 and LC3 levels in mouse primary neurons treated with decorin and/or bafilomycin A1. df Quantitative western blot of LAMP1, p-TFEB S142, T-TFEB and NBR1 levels in mouse primary neurons treated with decorin and/or bafilomycin A1. Brain homogenate from Atg7 conditional knockout mouse was loaded in the right most lane. g Phosphorylation profiling of proteins with ratios greater than 1.5 and lower than 0.6 comparing decorin-treated to non-treated. Scale bars, log10 of the ratio. h The 34 phospho-proteins identified in (g) were separately uploaded to GO and top 10 significantly enriched GO terms of biological processes are shown. (False discovery rate < 0.01). Data in (b, c, e, f) were analyzed by student’s t-test. Data are represented as mean ± SEM; *p < 0.05, ***p < 0.001; ns: not significant. Baf bafilomycin A1, p-TFEB S142 phosphorylated TFEB Ser142, T-TFEB total TFEB

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