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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis

Fig. 2

Mass spectrometry analysis of CSF from App knock-in mice identifies changes in ECM proteins. a, b Immunostaining and quantification of Aβ plaques in 12 months old App knock-in mouse brains. Scale bars, 1000 µm. (n = 4). c Number of proteins identified in CSF of the same mice and d PCA of proteins identified in all samples. (n = 4). e, f Number and PCA of significantly (p < 0.05) altered proteins. g Volcano plots displaying protein changes in AppNL-F/NL-F and (h) AppNL-G-F/NL-G-F mice. Dash line: p = 0.05. i Heatmaps showing significantly (p < 0.05) changed proteins in AppNL-F/NL-F mice and j AppNL-G-F/NL-G-F mice. Proteins were sorted into upregulated and downregulated in the App knock-in mice and by significance from highest to lowest (top to bottom). Data in (b) were analyzed by student’s t-test. Data are represented as mean ± SEM; ****p < 0.0001

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