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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Loss of glucocorticoid receptor phosphorylation contributes to cognitive and neurocentric damages of the amyloid-β pathway

Fig. 1

GR phosphorylation is altered in Alzheimer Disease. a Western blot of proteins in the prefrontal cortex (C, controls, A, Alzheimer, P, Parkinson). b Optical densities for the indicated protein markers. Quartiles and median of dataset from Min-to-Max. Significant differences with Mann–Whitney test between 21 C and 40 A is not observed between 21 C and 18 P (P = 0.8 for S267, P = 0.2 for S226, P = 0.4 for C99 and P = 0.9 for PHF-1). c Correlation between scores on the MMSE performed in a subset of patients within a year prior death (10 C and 29 A) and p-GR levels is positive (Pearson r = 0.35) for the site [S267] and negative (Pearson r = − 0.39) for the site [S226]. d Correlation between MMSE scores and the levels of C99 (Pearson r = − 0.07) and PHF-1 (Pearson r = − 0.46). e Cortisol receptor’s structure (modified from [37]) is highly disordered in its transactivation domain that is phosphorylated at multiple sites via distinct pathways altered in AD (red arrows)

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