Pathological and neurophysiological outcomes of seeding human-derived tau pathology in the APP-KI NL-G-F and NL-NL mouse models of Alzheimer’s Disease

Tok, S.; Maurin, H.; Delay, C.; Crauwels, D.; Manyakov, N. V.; Van Der Elst, W.; Moechars, D.; Drinkenburg, W. H. I. M.

doi:10.1186/s40478-022-01393-w

Table 2 Table of pairwise comparisons of baseline power spectra values from 1 to 50 Hz and low gamma frequency band range: (a) pairwise comparisons of baseline power spectra values from 1 to 50 Hz in between NL-G-F and NL-NL animals indicating no significant differences, (b) pairwise comparisons of baseline low gamma power spectra values in animals to be seeded at 6 months of age, NL-G-F and NL-NL animals

From: Pathological and neurophysiological outcomes of seeding human-derived tau pathology in the APP-KI NL-G-F and NL-NL mouse models of Alzheimer’s Disease

Electrode location	Pairwise comparison	Estimate	SE	df	T ratio	P value
(a) Post hoc pairwise contrasts of 1–50 Hz power spectra values at baseline
Entorhinal area	3mo NL-G-F-Buffer Pre–3mo NL-NL-Buffer Pre	0.3187	0.1818	116	1.7527	1.2681E−01
	3mo NL-G-F-Tau Pre–3mo NL-NL-Tau Pre	− 0.1970	0.1870	116	− 1.0534	3.8812E−01
	6mo NL-G-F-Buffer Pre–6mo NL-NL-Buffer Pre	0.2375	0.1828	116	1.2996	2.7450E−01
	6mo NL-G-F-Tau Pre–6mo NL-NL-Tau Pre	0.1870	0.1828	116	1.0230	4.0373E−01
Retrosplenial cortex	3mo NL-G-F-Buffer Pre–3mo NL-NL-Buffer Pre	0.0973	0.1818	116	0.5352	6.8099E−01
	3mo NL-G-F-Tau Pre–3mo NL-NL-Tau Pre	− 0.1678	0.1892	116	− 0.8869	4.7571E−01
	6mo NL-G-F-Buffer Pre–6mo NL-NL-Buffer Pre	0.0983	0.1828	116	0.5379	6.7922E−01
	6mo NL-G-F-Tau Pre–6mo NL-NL-Tau Pre	− 0.0460	0.1850	116	− 0.2487	8.5523E−01
Hippocampal formation	3mo NL-G-F-Buffer Pre–3mo NL-NL-Buffer Pre	0.0987	0.1818	116	0.5427	6.7634E−01
	3mo NL-G-F-Tau Pre–3mo NL-NL-Tau Pre	0.2752	0.1870	116	1.4714	2.0967E−01
	6mo NL-G-F-Buffer Pre–6mo NL-NL-Buffer Pre	0.1285	0.1828	116	0.7032	5.8077E−01
	6mo NL-G-F-Tau Pre–6mo NL-NL-Tau Pre	0.0568	0.1850	116	0.3072	8.2146E−01
Thalamus	3mo NL-G-F-Buffer Pre–3mo NL-NL-Buffer Pre	0.2593	0.1818	116	1.4259	2.2588E−01
	3mo NL-G-F-Tau Pre–3mo NL-NL-Tau Pre	0.1300	0.1879	116	0.6922	5.8712E−01
	6mo NL-G-F-Buffer Pre–6mo NL-NL-Buffer Pre	0.3864	0.1828	116	2.1145	6.0009E−02
	6mo NL-G-F-Tau Pre–6mo NL-NL-Tau Pre	− 0.0003	0.1828	116	− 0.0017	9.9916E−01
(b) Post hoc pairwise contrasts of low gamma power spectra values at baseline
Entorhinal area	6mo NL-G-F-Buffer Pre–6mo NL-NL-Buffer Pre	− 0.2466	0.1116	118	− 2.2094	3.8786E−02
Entorhinal area	6mo NL-G-F-Tau Pre–6mo NL-NL-Tau Pre	− 0.3409	0.1120	118	− 3.0429	4.3913E−03
Retrosplenial cortex	6mo NL-G-F-Buffer Pre–6mo NL-NL-Tau Pre	− 0.3358	0.1266	118	− 2.6521	1.3000E−02
Retrosplenial cortex	6mo NL-G-F-Tau Pre–6mo NL-NL-Tau Pre	− 0.4319	0.1122	118	− 3.8495	3.3214E−04
Hippocampal formation	6mo NL-G-F-Buffer Pre–6mo NL-NL-Buffer Pre	− 0.4677	0.1123	118	− 4.1661	1.0783E−04
Hippocampal formation	6mo NL-G-F-Tau Pre–6mo NL-NL-Tau Pre	− 0.4748	0.1129	118	− 4.2070	9.2651E−05
Thalamus	6mo NL-G-F-Buffer Pre–6mo NL-Buffer Pre	− 0.1635	0.1116	118	− 1.4648	0.1747
Thalamus	6mo NL-G-F-Tau Pre–6mo NL-Tau Pre	− 0.4273	0.1121	118	− 3.8130	0.0004

SE refers to standard error. Df refers to degrees of freedom. Estimate refers to the estimated difference in value between pairwise comparisons. Pre refers to pre-injection recordings

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