Table 1 Table containing pairwise comparisons of quantified amyloid and AT8-positive tau pathology: (a) comparison of AT8-positive tau pathology in NL-G-F-Tau and NL-Tau mice between 1 and 5 m.p.i. across brain regions, (b) comparison of AT8-positive tau pathology between NL-G-F-Tau and NL-Tau animals at 5 m.p.i, (c) comparison of amyloid pathology between NL-G-F-tau and NL-G-F-buffer animals at 5 m.p.i
Brain region | Pairwise comparison | Estimate | SE | df | T ratio | P value |
|---|---|---|---|---|---|---|
(a) Post hoc pairwise contrasts of AT8-positive tau pathology in NL-G-F and NL-NL animals between 1 and 5 m.p.i | ||||||
Entorhinal area | 3mo NL-G-F-Tau 1mpi–3mo NL-G-F-Tau 5mpi | − 0.0078 | 0.0009 | 69 | − 8.2517 | 1.0193E−10 |
6mo NL-G-F-Tau 1mpi–6mo NL-G-F-Tau 5mpi | − 0.0053 | 0.0009 | 69 | − 5.5507 | 4.2413E−06 | |
Isocortex | 3mo NL-G-F-Tau 1mpi–3mo NL-G-F-Tau 5mpi | − 0.0119 | 0.0009 | 69 | − 12.5660 | 3.2351E−17 |
6mo NL-G-F-Tau 1mpi–6mo NL-G-F-Tau 5mpi | − 0.0095 | 0.0009 | 69 | − 10.0039 | 8.1906E−14 | |
Hippocampal region | No significant differences | |||||
Thalamus | No significant differences | |||||
(b) Post hoc pairwise contrasts of AT8-positive tau pathology in NL-G-F animals between 3 and 6 months of age at 5 m.p.i | ||||||
Entorhinal area | 3mo NL-G-F-Tau 5mpi–3mo NL-Tau 5mpi | 0.0075 | 0.0010 | 69 | 7.5953 | 1.3175E−09 |
6mo NL-G-F-Tau 5mpi–6mo NL-Tau 5mpi | 0.0069 | 0.0009 | 69 | 7.3084 | 4.0347E−09 | |
Isocortex | 3mo NL-G-F-Tau 5mpi–3mo NL-Tau 5mpi | 0.0107 | 0.0010 | 69 | 10.9388 | 2.0638E−15 |
6mo NL-G-F-Tau 5mpi–6mo NL-Tau 5mpi | 0.0105 | 0.0009 | 69 | 11.1057 | 1.1349E−15 | |
Hippocampal formation | No significant differences | |||||
Thalamus | No significant differences | |||||
(c) Post hoc pairwise contrasts of amyloid pathology between NL-G-F-tau and NL-G-F-buffer animals at 5 m.p.i | ||||||
Entorhinal area | 3mo NL-G-F-Buffer 5mpi–3mo NL-G-F-Tau 5mpi | 0.0016 | 0.0007 | 69 | 2.3416 | 3.6999E−02 |
6mo NL-G-F-Buffer 5mpi–6mo NL-G-F-Tau 5mpi | − 0.0036 | 0.0007 | 69 | − 5.1335 | 5.2315E−06 | |
Isocortex | 3mo NL-G-F-Buffer 5mpi–3mo NL-G-F-Tau 5mpi | 0.0022 | 0.0007 | 69 | 3.3480 | 2.4457E−03 |
6mo NL-G-F-Buffer 5mpi–6mo NL-G-F-Tau 5mpi | − 0.0020 | 0.0007 | 69 | − 2.8146 | 1.0855E−02 | |
Hippocampal formation | 6mo NL-G-F-Buffer 5mpi–6mo NL-G-F-Tau 5mpi | − 0.0021 | 0.0007 | 69 | − 3.0085 | 6.4259E−03 |
Thalamus | No significant differences | |||||