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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Pathological and neurophysiological outcomes of seeding human-derived tau pathology in the APP-KI NL-G-F and NL-NL mouse models of Alzheimer’s Disease

Fig. 1

Illustrated overview of the experimental study, containing the workflow for histological and electrophysiological assessment. a Timeline for both histological and electrophysiological cohorts indicating sample sizes, recording, euthanasia and injection timepoints for two age groups. B+n refers to n days after birth. D+n refers to n days after injection. b Histological workflow illustrating surgical procedure, whole-brain immunostaining, light-sheet imaging and quantification. M.p.i refers to months-post injection. c Workflow for electrophysiological assessment showing EEG recording, activity detection, and vigilance-controlled analysis readouts

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Acta Neuropathologica Communications

ISSN: 2051-5960

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