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Table 6 The top 50 significantly differentially expressed proteins in FTD-GRN vs NDC and FTD-MAPT vs NDC

From: Distinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia

 

Frontal cortical tissue of FTD-GRN vs NDC

  

Temporal cortical tissue of FTD-MAPT vs NDC

  

Direction of differential expression

Gene Symbol

Fold Change

Statistical q value

Gene Symbol

Fold Change

Statistical q value

Higher

PHYHD1

7.434

0.0001099

SUCLG2

9.226

0.0021797

Higher

ICAM1

6.803

0.0003298

GFAP

6.468

0.0005181

Higher

CD44

6.718

0.0011453

H1-0

6.366

0.0083540

Higher

GFAP

6.439

0.0001099

CD44

5.912

0.0221017

Higher

TNC

4.843

0.0025774

FAT3

4.893

0.0006696

Higher

PPIA

4.158

0.0013982

PHYHD1

4.857

0.0079645

Higher

FAT3

4.156

0.0008582

TNC

4.800

0.0019158

Higher

GSTM5

3.974

0.0233293

ITGA7

4.289

0.0053771

Higher

BLVRB

3.748

0.0055936

GSTM5

3.971

0.0028718

Higher

SORD

3.653

0.0092284

SDC3

3.882

0.0123535

Higher

GJA1

3.579

0.0037439

PLSCR4

3.795

0.0005181

Higher

ARHGDIB

3.473

0.0035394

TNS3

3.731

0.0005181

Higher

HIKESHI

3.399

0.0048696

GSTM3

3.692

0.0005181

Higher

CSRP1

3.336

0.0001099

PLCD3

3.624

0.0069908

Higher

FKBP1A

3.304

0.0008582

PYGM

3.569

0.0005181

Higher

PLSCR4

3.232

0.0001799

PPIA

3.479

0.0008116

Higher

ARHGDIA

3.107

0.0127071

PRODH

3.472

0.0041525

Higher

ISYNA1

3.104

0.0248770

VAMP5

3.443

0.0058829

Higher

AKR1B1

3.024

0.0101091

CSRP1

3.407

0.0022148

Higher

CBR1

2.924

0.0013718

HEPACAM

3.378

0.0006236

Higher

GSTM2

2.904

0.0001484

EGFR

3.353

0.0022489

Higher

PNP

2.882

0.0008582

GJA1

3.352

0.0008976

Higher

TPR

2.821

0.0031321

NQO1

3.267

0.0275547

Higher

HEPACAM

2.798

0.0001099

FKBP1A

3.244

0.0338166

Higher

GSPT1

2.791

0.0080283

SNTB1

3.180

0.0053499

Lower

CEP128

0.145

0.0066177

HNMT

0.107

0.0125724

Lower

LPCAT4

0.194

0.0017604

ERMN

0.160

0.0009540

Lower

RDH13

0.222

0.0072139

MOG

0.161

0.0009540

Lower

CPLX1

0.226

0.0346641

OPALIN

0.176

0.0042780

Lower

UBAP2L

0.244

0.0082093

PANK4

0.198

0.0066545

Lower

CACNG8

0.252

0.0129590

MOBP

0.209

0.0010363

Lower

FBXL18

0.257

0.0014650

JAM3

0.210

0.0046333

Lower

CACNG3

0.278

0.0411538

PLLP

0.234

0.0122430

Lower

PEX16

0.291

0.0089505

STAT1

0.236

0.0006236

Lower

HABP4

0.303

0.0005289

MBP

0.248

0.0013509

Lower

SNCG

0.313

0.0006494

MAG

0.253

0.0007440

Lower

MRPS36

0.317

0.0157407

MAP6D1

0.258

0.0005181

Lower

TIMM13

0.332

0.0126697

DBNL

0.263

0.0152205

Lower

NIPSNAP3B

0.344

0.0093255

HSPA12B

0.268

0.0212848

Lower

MAG

0.352

0.0188804

SNCG

0.278

0.0006696

Lower

UBQLN1

0.361

0.0063254

CPLX1

0.286

0.0009540

Lower

IGSF9B

0.375

0.0038853

LGI3

0.291

0.0005181

Lower

KIAA1211L

0.378

0.0031165

HABP4

0.292

0.0064298

Lower

SYNPO

0.378

0.0003298

CPNE5

0.305

0.0115622

Lower

NDUFV3

0.390

0.0324149

CCAR1

0.315

0.0165266

Lower

TFRC

0.390

0.0031321

SIRT2

0.330

0.0019158

Lower

TAX1BP1

0.392

0.0006785

TIMM9

0.357

0.0271267

Lower

KATNAL1

0.397

0.0219467

RTN4RL2

0.359

0.0143297

Lower

VAMP4

0.401

0.0091035

PLP1

0.360

0.0019158

Lower

MAP7D1

0.402

0.0361734

SULT4A1

0.363

0.0425741

  1. The top 25 higher and top 25 lower significant differentially expressed proteins (q < 0.05) with the largest fold changes are listed for frontal cortical samples of FTD-GRN vs NDC and for temporal cortical samples of FTD-MAPT vs NDC
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Acta Neuropathologica Communications

ISSN: 2051-5960

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