Table 1 Demographic, clinical, and post-mortem characteristics for cortical frontal and temporal samples from the RiMOD-FTD cohort

Demographics

Female, n (%)

F: 7/11 (63,6)

F: 5/8 (62,5)

F: 5/11 (45,5)

T: 5/8 (62,5)

T: 5/9 (55,6)

T: 5/13 (38,5)

Age, median (range)

F: 83 (60–91)

F: 65 (52–76) ‡

F: 60 (49–75) ‡

T: 83 (60–91)

T: 65 (52–76) †

T: 60 (46–75) ‡

Clinical characteristics

Genetic mutation (n)

n/a

C105fs (1)

G272V (4)

G24X (1)

P301L (8)

G125X (1)

R406V (1)

G300X (1)

S82VfsX174 (4)

C31LfsTer34 (1)

Disease pathology (n)

NA

F | T:

F | T:

• Atypical Pick’s disease

– | –

4 | 4

• Tau

– | –

7 | 9

• TDP-type A

8 | 8

– | –

• Undetermined

– | 1

– | –

ApoE profile (n)

F | T:

F | T:

F | T:

• 32

– | –

2 | 2

1 | 1

• 33

6 | 3

3 | 3

5 | 7

• 42

– | –

– | –

– | –

• 43

2 | 2

– | –

3 | 3

• 44

1 | 1

– | –

1 | 1

• Unknown

2 | 2

3 | 4

1 | 1

Post-mortem determinants

Post-mortem delay, median (range)

F: 05:50 (03:35–08:00)

F: 05:00 (03:35–06:05) *

F: 05:23 (04:10–11:30)

T: 05:54 (03:35–08:00)

T: 05:00 (03:35–06:05)

T: 05:35 (04:10–11:30)

Cerebrospinal fluid pH, median (range)

F: 6.75 (6.26–7.20)

F: 6.36 (6.10–6.52) †

F: 6.46 (5.91–6.64) †

T: 6.72 (6.26–7.20)

T: 6.36 (6.10–6.52) †

T: 6.46 (5.91–6.64) *

Brain weight in grams, median (range)

F: 1188 (943–1590)

F: 954 (830–1242) *

F: 962 (652–1188) †

T: 1130 (943–1590)

T: 954 (830–1242) *

T: 1011 (652–1188) *

Braak score, median (range)

F: 1 (0–2)

n/a

n/a

T: 2 (0–2)