Fig. 4

Figure 4-I GO analysis shows distinct involvement of metabolic and immune processes and mitochondrial functioning in FTD-GRN. A GO term enrichment analysis on lower (n = 331) and higher (n = 248) differentially expressed proteins in frontal cortical FTD-GRN vs NDC. Only classical GO terms (BP/CC/MF) are taken into account, and only ‘Best Per Parent’ GO terms are shown. The number of proteins in each term is listed. GO terms are further categorized into GO groups. ‘Metabolism’, ‘Immune’, and ‘Mitochondria’ GO groups are distinctly present in FTD-GRN when compared with FTD-MAPT. B EWCE analysis of the ‘Metabolism’ GO group shows the involvement of astrocytes (p = 0) in these processes. C EWCE analysis of the ‘Immune’ GO group shows the involvement of endothelial cells (p = 0.00035) in these processes. D EWCE analysis of the ‘Mitochondria’ GO group shows enrichment for both excitatory and inhibitory neurons (p = 0.0056 and p = 0.0049, respectively). Figure 4-II GO analysis shows distinct involvement of RNA processing, axons, ion transport, and the plasma membrane in FTD-MAPT. A GO term enrichment analysis on lower (n = 246) and higher (n = 242) differentially expressed proteins in temporal cortical FTD-MAPT vs NDC. Only classical GO terms (BP/CC/MF) are taken into account, and only ‘Best Per Parent’ GO terms are shown. The number of proteins in each term is listed. GO terms are further categorized into GO groups. ‘RNA processing’, ‘Axon’, ‘Ion transport’, and ‘Plasma membrane’ GO groups are distinctly present in FTD-MAPT when compared with FTD-GRN. B EWCE analysis of the ‘RNA processing’ GO group shows no specific cell type enrichment. C EWCE analysis of the ‘Axon’ GO group shows involvement of excitatory neurons (p = 0) and oligodendrocytes (p = 0.0056). D EWCE analysis of the ‘Ion transport’ GO group shows enrichment for both excitatory and inhibitory neurons (p = 0.001 and p = 0, respectively). E EWCE analysis of the ‘Plasma membrane’ GO group shows involvement of excitatory neurons (p = 0) and oligodendrocytes (p = 0). EWCE analysis is performed using bootstrapped t-test statistics with a multiple testing correction done by the Benjamini-Hochberg method. Adhes.; adhesion, Develop.; development, Extracell.; extracellular, Exc.; excitatory, Inh.; Inhibitory, Memb.; membrane; NTs; Neurotransmitters, Oxidored.; oxidoreductase, PM; plasma membrane, Tis dev.; tissue development, Transp.; transport, s.d.; standard deviation